NETURE NEUROSCIENCE

Nature Neuroscience
(ISSN 1097-6256)
Nature Publishing Group

Description,
Retinitis pigmentosa is characterized by an initial loss of rod photoreceptors followed by a progressive loss of
cones, although the known mutations causing retinitis pigmentosa are all in rod-specific genes. Punzo et al. now report that rod-specific mutations in the insulin/mTOR pathway may contribute to cone death as a result
of photoreceptor starvation. The cover depicts phosphorylated mTOR in dorsal cone receptors (cell bodies
in magenta, outer segments in green and mTOR in red). (pp 5 and 44)
Training restores degraded cortical processing (p 26)
Homotypic repulsion mediates retinal tiling (p 35)
Paired lateral neuron function in olfactory learning (p 53)
Stimulus contrast modulates functional connectivity (pp 10 and 70)
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